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Kristian Helin Selected Research

Histone Demethylases

12/2019Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.
1/2019HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases.
5/2015Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.
3/2015The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice.
3/2014The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development.
12/2013Histone lysine demethylases as targets for anticancer therapy.
4/2013The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3.
3/2013The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.
4/2012Identification of catechols as histone-lysine demethylase inhibitors.
11/2010Histone demethylases in development and disease.
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Kristian Helin Research Topics

Disease

60Neoplasms (Cancer)
03/2022 - 02/2002
5Leukemia
11/2019 - 06/2007
4Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
03/2022 - 05/2015
3Carcinogenesis
01/2020 - 06/2007
3Inflammation (Inflammations)
01/2019 - 06/2015
2Colonic Neoplasms (Colon Cancer)
01/2020 - 07/2013
2Breast Neoplasms (Breast Cancer)
01/2019 - 07/2004
2Glioma (Gliomas)
11/2013 - 01/2009
2Glioblastoma (Glioblastoma Multiforme)
10/2013 - 01/2009
2Neuroblastoma
08/2013 - 06/2011
2Acute Promyelocytic Leukemia
03/2013 - 06/2007
2Multiple Myeloma
06/2011 - 05/2011
2Retinoblastoma (Glioblastoma, Retinal)
11/2007 - 06/2004
1Ovarian Neoplasms (Ovarian Cancer)
12/2021
1Bites and Stings (Sting)
12/2021
1Granulosa Cell Tumor
01/2020
1Neurodevelopmental Disorders
12/2019
1Hematologic Neoplasms (Hematological Malignancy)
01/2019
1Insulin Resistance
01/2019
1Psoriasis (Pustulosis Palmaris et Plantaris)
12/2018
1Oligodendroglioma
01/2018
1Brain Neoplasms (Brain Tumor)
04/2017
1Diffuse Intrinsic Pontine Glioma
04/2017
1Infections
06/2015
1Chronic Disease (Chronic Diseases)
06/2015
1Respiratory Syncytial Virus Infections
06/2015
1Melanoma (Melanoma, Malignant)
04/2015
1Colorectal Neoplasms (Colorectal Cancer)
01/2014
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
12/2013
1Medulloblastoma
10/2013
1Carcinoma (Carcinomatosis)
07/2013
1Respiratory Insufficiency (Respiratory Failure)
04/2013
1Autoimmune Diseases (Autoimmune Disease)
01/2013
1Skin Neoplasms (Skin Cancer)
06/2012

Drug/Important Bio-Agent (IBA)

24Proteins (Proteins, Gene)FDA Link
01/2022 - 06/2004
12Histone DemethylasesIBA
12/2019 - 05/2008
9ChromatinIBA
12/2019 - 05/2006
8Transcription Factors (Transcription Factor)IBA
12/2019 - 01/2009
7Pharmaceutical PreparationsIBA
01/2020 - 07/2004
6EnzymesIBA
04/2016 - 07/2006
5Histones (Histone)IBA
01/2020 - 07/2006
5Polycomb Repressive Complex 2IBA
12/2016 - 04/2004
3Histone MethyltransferasesIBA
03/2022 - 04/2010
3RNA (Ribonucleic Acid)IBA
01/2020 - 07/2004
3Biological ProductsIBA
12/2013 - 05/2008
3DNA (Deoxyribonucleic Acid)IBA
11/2013 - 10/2005
3Polycomb-Group ProteinsIBA
11/2009 - 04/2004
3Retinoblastoma ProteinIBA
11/2003 - 02/2002
2InterferonsIBA
03/2022 - 12/2021
2Fluorouracil (Carac)FDA LinkGeneric
01/2020 - 07/2013
2Lysine (L-Lysine)FDA Link
01/2020 - 04/2008
2CytokinesIBA
12/2018 - 06/2015
2Small Interfering RNA (siRNA)IBA
03/2014 - 07/2013
2MicroRNAs (MicroRNA)IBA
01/2014 - 01/2014
2Tretinoin (Retinoic Acid)FDA LinkGeneric
03/2013 - 06/2011
2Messenger RNA (mRNA)IBA
06/2011 - 06/2009
2Histone-Lysine N-MethyltransferaseIBA
06/2011 - 05/2011
2GemininIBA
08/2004 - 05/2004
1Adenosine Triphosphatases (ATPase)IBA
01/2022
1cyclic guanosine monophosphate-adenosine monophosphateIBA
12/2021
1Immune Checkpoint InhibitorsIBA
12/2021
1Deubiquitinating EnzymesIBA
01/2020
1Mutant Proteins (Protein, Mutant)IBA
01/2020
1Biomarkers (Surrogate Marker)IBA
11/2019
1Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA
11/2019
1Insulin (Novolin)FDA Link
01/2019
1LipidsIBA
01/2019
1Trastuzumab (Herceptin)FDA Link
01/2019
1Glucose (Dextrose)FDA LinkGeneric
01/2019
1Epoxide HydrolasesIBA
01/2019
1Lapatinib (GW572016)FDA Link
01/2019
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
12/2018
1Interleukin-17 (Interleukin 17)IBA
12/2018
1Interleukin-23 (Interleukin 23)IBA
12/2018
1MitogensIBA
01/2018
1dipinacoline glutamateIBA
04/2017
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
04/2017
1Interferon Type IIBA
06/2015
1Interleukin-4 (Interleukin 4)IBA
06/2015
1Interleukin-5 (Interleukin 5)IBA
06/2015
1Interleukin-13IBA
06/2015
1Leucine-Rich Repeat ProteinsIBA
05/2015
1DioxygenasesIBA
05/2015
1cytidylyl-3'-5'-guanosineIBA
05/2015
1Cyclin-Dependent Kinase Inhibitor p16IBA
04/2015
1ras ProteinsIBA
10/2014
1Codon (Codons)IBA
09/2014
1Histone Deacetylase InhibitorsIBA
12/2013
1Histone Deacetylases (Histone Deacetylase)IBA
12/2013
1A-Form DNA (A-DNA)IBA
12/2013
1Histone Acetyltransferases (Histone Acetyltransferase)IBA
10/2013
1AcetyltransferasesIBA
10/2013
1Phosphotransferases (Kinase)IBA
07/2013
1Glycogen Synthase Kinase 3 betaIBA
07/2013
1Mixed Function Oxygenases (Monooxygenases)IBA
10/2012
1Oncogene Proteins (Oncogene Protein)IBA
05/2011

Therapy/Procedure

12Therapeutics
01/2022 - 04/2003
2Transplantation
01/2019 - 03/2014
2Drug Therapy (Chemotherapy)
07/2013 - 06/2011
2Aftercare (After-Treatment)
06/2011 - 04/2003